Functional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy

نویسندگان

  • Masamitsu Oshima
  • Kaoru Inoue
  • Kei Nakajima
  • Tetsuhiko Tachikawa
  • Hiromichi Yamazaki
  • Tomohide Isobe
  • Ayaka Sugawara
  • Miho Ogawa
  • Chie Tanaka
  • Masahiro Saito
  • Shohei Kasugai
  • Teruko Takano-Yamamoto
  • Takashi Inoue
  • Katsunari Tezuka
  • Takuo Kuboki
  • Akira Yamaguchi
  • Takashi Tsuji
چکیده

Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid artificial organ replacement therapy.

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عنوان ژورنال:

دوره 4  شماره 

صفحات  -

تاریخ انتشار 2014